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Cat#: 109P06
序列（三字母）：H-Gly-His-Arg-Pro-NH? acetate salt
序列（單字母）：GHRP-NH?
類似名：GHRP amide
分子式：C??H??N??O?
分子量：464.53
CAS#：209623-54-1
合成方法：固相合成
存儲條件：-20 ± 5 °C，避光，干燥
應用：Cardiovascular System & Diseases Hematology
描述：The central E region of fibrin contains two sets of polymerization knobs, A and B, that are cryptic in fibrinogen but become exposed after thrombin cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB) from the N-terminus of the Aα- and Bβ-chains, respectively. The location of the binding holes and possible models for knob-hole interactions are known from X-ray crystallographic studies using synthetic peptide analogs of knobs A and B. When fibrinogen fragment D and double-D are crystallized in the presence of both peptide analogs, the knob A peptide mimic H-Gly-Pro-Arg-Pro-NH? (GPRP-amide) forms H-bond interactions with residues γ364Asp, γ330Asp, γ329Gln, and γ340His found in hole a. In the same manner, the knob B peptide mimic H-Gly-His-Arg-Pro-NH? (GHRP-amide) interacts with residues Bβ397Glu, Bβ398Asp, and Bβ432Asp in hole b.